MENSTRUAL-CYCLE DEPENDENT EXPRESSION OF CD44 IN NORMAL HUMAN ENDOMETRIUM
MENSTRUAL-CYCLE DEPENDENT EXPRESSION OF CD44 IN NORMAL HUMAN ENDOMETRIUM
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DOI：
10.1016/0046-8177(95)90008-x
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发表时间：
1995-08-01
期刊：
影响因子：
3.3
通讯作者：
NAKAMURA, M
中科院分区：
文献类型：
--
作者：
YAEGASHI, N;FUJITA, N;NAKAMURA, M
CD44是已知为透明质酸受体的细胞表面糖蛋白，其在淋巴细胞归巢和癌症转移中起作用。我们以前已经表明，CD44分子在正常子宫内膜组织中表达。在这项研究中，我们用化学方法检测了CD44糖蛋白在正常人子宫内膜组织中的表达，以深入了解CD44分子的作用。在增殖期的11例患者中未观察到CD 44标准形式的表达。而19例分泌期乳腺癌中13例抗CD44标准型抗体强阳性，CD44阳性者均为分泌中晚期乳腺癌。在13例CD44阳性的ESTA中，4例也为外显子z6的CD44变体阳性。CD44分子存在于除管腔细胞表面之外的所有表面。这些结果表明CD 44的表达取决于月经周期，提示CD 44分子可能参与受精卵在子宫内膜的着床。版权所有（C）1995由W.B.桑德斯公司
CD44 is a cell surface glycoprotein known to be a hyaluronate receptor, which functions in lymphocyte homing and cancer metastasis. We have previously shown that CD44 molecules are expressed in normal endometrial tissue. In this study we immunohistochemically examined expression of CD44 glycoproteins in normal human endometrial tissue to gain insight into roles of CD44 molecules. No expression of the CD44 standard form was observed with 11 endometria in the proliferative phase. On the contrary, 13 of 19 secretory phase endometria were stained intensely by anti-CD44 standard form antibody; all CD44-positive cases were in the mid and late secretory phases. Among the 13 CD44-positive endometria, four also were positive for the CD44 variant with exon z6. CD44 molecules were present at all but the luminal cell surfaces. These results indicate that expression of CD44 depends on menstrual cycle, suggesting that CD44 molecules might be involved in implantation of fertilized ovum in endometrium. Copyright (C) 1995 by W.B. Saunders Company.