Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants
Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants
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针对源自植物的耐甲氧西林金黄色葡萄球菌的新型抗菌方式
DOI：
10.1080/10408398.2018.1541865
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发表时间：
2019-06-27
影响因子：
10.2
通讯作者：
Ding, Tian
中科院分区：
文献类型：
--
作者：
Li, Jiao;Liu, Donghong;Ding, Tian
摘要 耐甲氧西林金黄色葡萄球菌（MRSA）是一种臭名昭著的细菌病原体，可导致高死亡率和发病率。由于多重耐药性的出现，抗生素治疗对相关感染迅速变得无效。天然产物，特别是源自植物的天然产物，已通过不同的机制被证明是具有独特抗菌特性的有效制剂。本综述阐释了MRSA的耐药机制，旨在克服公共卫生威胁。此外，最近有关植物抗菌剂的研究也对 MRSA 显示出显着的抗菌活性，包括植物粗提取物和纯化的植物源生物活性化合物。还总结了植物抗菌剂的新型抗 MRSA 模式，例如改变外排泵、抑制丙酮酸激酶以及扰乱 MRSA 中的群体感应，这些模式可能是未来抗菌药物开发的有希望的替代方案。
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious bacterial pathogen that induces high mortality and morbidity. Due to the emergence of multiple resistance, antibiotic treatments are rapidly becoming ineffective for the related infections. Natural products, especially those derived from plants, have been proven to be effective agents with unique antibacterial properties through different mechanisms. This review interprets the resistance mechanisms of MRSA with the aim to conquer public health threat. Further, recent researches about plant antimicrobials that showed remarkable antibacterial activity against MRSA are recorded, including the crude plant extracts and purified plant-derived bioactive compounds. Novel anti-MRSA modalities of plant antimicrobials such as alteration in efflux pump, inhibition of pyruvate kinase, and disturbance of quorum sensing in MRSA are also summarized which may be promising alternatives to antibacterial drug development in future.