FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
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DOI：
10.1142/s0219519415500773
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发表时间：
2015-10-01
影响因子：
0.8
通讯作者：
Knight, M. M.
中科院分区：
文献类型：
--
作者：
Chen, Jinju;Bader, D. L.;Knight, M. M.
细胞的机械性质在调节细胞功能的许多方面是重要的。细胞可能对2D板和3D支架有不同的反应。本研究采用有限元分析方法研究了软骨细胞在二维玻璃板上和软骨细胞在三维支架上的力学变形。在这两种不同的压缩测试中，电池的弹性特性不同。这是因为细胞感受到不同的环境（2D板和3D结构），这可能会改变其结构和机械特性。它揭示了细胞的表观泊松比如何随施加的应变而变化，取决于其机械环境（例如，支架和细胞外基质的弹性模量和泊松比），其调节细胞力学。此外，细胞核的弹性模量在细胞接种支架的细胞泊松比的确定中也起重要作用。它还揭示了细胞的固有泊松比不能通过将测量的表观泊松比外推到零应变来获得，特别是当支架的泊松比与细胞完全不同时。
The mechanical properties of cells are important in regulation of many aspects of cell functions. The cell may respond differently to a 2D plate and a 3D scaffold. In this study, the finite element analysis (FEA) was adopted to investigate mechanical deformation of chondrocyte on a 2D glass plate and chondrocyte seeded in a 3D scaffold. The elastic properties of the cell differ in these two different compression tests. This is because that the cell sensed different environment (2D plate and 3D construct) which can alter its structure and mechanical properties. It reveals how the apparent Poisson's ratio of a cell changes with the applied strain depends on its mechanical environment (e.g., the elastic moduli and Poisson's ratios of the scaffold and extracellular matrix) which regulates cell mechanics. In addition, the elastic modulus of the nucleus also plays a significant role in the determination of the Poisson's ratio of the cell for the cells seeded scaffold. It also reveals the intrinsic Poisson's ratio of the cell cannot be obtained by extrapolating the measured apparent Poisson's ratio to zero strain, particularly when scaffold's Poisson's ratio is quite different from the cell.