Involvement of the hepatic branch of the vagus nerve in the regulation of plasma adipokine levels in rats fed a high-fructose diet
Involvement of the hepatic branch of the vagus nerve in the regulation of plasma adipokine levels in rats fed a high-fructose diet
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DOI：
10.1016/j.jnutbio.2019.06.003
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发表时间：
2019-09-01
影响因子：
5.6
通讯作者：
Takano-Ishikawa, Yuko
中科院分区：
文献类型：
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作者：
Hashimoto, Naoto;Wakagi, Manabu;Takano-Ishikawa, Yuko
高果糖饮食不仅与肝脏中的脂肪积累有关，还与血液脂肪因子水平有关。一些研究表明体液因素参与脂肪因子的调节。然而，迷走神经在脂肪因子表达中的作用尚不完全清楚。我们试图研究迷走神经肝支 (HBVN) 在高果糖 (HFr) 饮食大鼠血浆脂肪因子水平调节中的作用。对大鼠进行肝迷走神经切断术（Vx）或假手术；此后，他们接受对照饮食（CT）或 HFr 饮食 6 周。第六周，进行口服葡萄糖耐量试验（OGTT）。在假手术组中，HFr 组血浆瘦素和脂联素水平显着低于对照组。相反，在Vx组中，两个饮食组各自的脂肪因子水平没有差异。在OGTT中，血浆瘦素水平与血浆胰岛素水平的曲线下面积（AUC）和某些点的胰岛素水平显着相关。此外，血浆瘦素水平与血浆脂联素水平的比率与血浆胰岛素水平的AUC相关。然而，血浆脂联素水平本身与血浆胰岛素水平和胰岛素AUC不相关。因此，我们发现 HBVN 在 HFr 喂养的大鼠血浆瘦素和脂联素水平下调中发挥着关键作用。 (C) 2019 Elsevier Inc. 保留所有权利。
High-fructose diets are associated with not only fat accumulation in liver but also blood adipokine levels. Some studies have shown the involvement of humoral factors in the regulation of adipokines. However, the role of the vagus nerve in expression of adipokines is not fully understood. We attempted to investigate the involvement of the hepatic branch of the vagus nerve (HBVN) in the regulation of plasma adipokine levels in rats fed a high-fructose (HFr) diet. Rats underwent hepatic vagotomy (Vx) or sham operation; thereafter, they were fed a control diet (CT) or HFr diet for 6 weeks. At the sixth week, the oral glucose tolerance test (OGTT) was performed. In the sham-operated group, plasma leptin and adiponectin levels were significantly lower in the HFr group than those in the control group. In contrast, in the Vx group, there was no difference in the respective adipokine levels of the two dietary groups. In OGTT, plasma leptin levels were significantly correlated to the area under the curve (AUC) of plasma insulin levels and insulin levels at some points. Further, the ratio of plasma leptin levels to plasma adiponectin levels was correlated with the AUC of plasma insulin levels. However, the plasma adiponectin level itself did not correlate with plasma insulin levels and insulin AUC. Thus, we showed that HBVN played a key role in down-regulating plasma leptin and adiponectin levels in HFr-fed rats. (C) 2019 Elsevier Inc. All rights reserved.