The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
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DOI：
10.1097/pgp.0b013e31826916c7
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发表时间：
2012-07-01
影响因子：
3.7
通讯作者：
Wilbur, David C.
中科院分区：
文献类型：
--
作者：
Darragh, Teresa M.;Colgan, Terence J.;Wilbur, David C.
下肛门生殖道人乳头瘤病毒（HPV）相关鳞状病变的术语有着悠久的历史，其特征是来自多个专业的不同诊断术语。它通常不能反映HPV生物学和发病机制的现有知识。召集了一个共识过程，以推荐下肛门生殖器部位统一的术语。目标是创建一个组织病理学命名系统，反映HPV生物学的当前知识，最佳地使用可用的生物标志物，并促进不同医学专业之间的明确沟通。低位肛门生殖器鳞状术语（LAST）项目由美国病理学家学院和美国阴道镜和宫颈病理学会共同赞助，包括5个工作组; 3个工作组进行全面的文献综述并制定建议草案。另一个工作组提供了历史背景，第五个工作组将继续促进落实最后一个小组的建议。经过公开评论期后，建议草案提交给了LAST工作组成员、顾问以及包括专业协会和政府机构在内的35个利益攸关方组织的代表参加的共识会议。在协商一致会议上最后确定并表决了各项建议。最终批准的建议标准化了所有下肛门生殖道部位HPV相关鳞状上皮内病变和表面浸润性鳞状细胞癌的生物学相关组织病理学术语，并详细说明了特定生物标志物的适当使用，以澄清组织学解释并提高诊断准确性。还制定了一项在实践界传播和监测建议执行情况的计划。实施的建议将促进病理学家和他们的临床同事之间的沟通，提高组织学诊断的准确性，最终目标是提供最佳的患者护理。
The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.