Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource
Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource
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DOI：
10.1038/s41588-020-0693-3
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发表时间：
2020-09-09
期刊：
影响因子：
30.8
通讯作者：
Ascher, David B.
中科院分区：
文献类型：
--
作者：
Portelli, Stephanie;Olshansky, Moshe;Ascher, David B.
COVID-19大流行的出现促使全球急于揭示基本的生物学机制，以指导有效的疫苗和药物开发。尽管这种病毒很新奇，但全球测序工作已经确定了分离株之间的基因组变异。为了能够轻松探索SARS-CoV-2突变对感染、宿主免疫和药物开发的潜在影响并进行空间可视化，我们开发了COVID-3D（）。
The emergence of the COVID-19 pandemic has spurred a global rush to uncover basic biological mechanisms to inform effective vaccine and drug development. Despite the novelty of the virus, global sequencing efforts have already identified genomic variation across isolates. To enable easy exploration and spatial visualization of the potential implications of SARS-CoV-2 mutations in infection, host immunity and drug development, we have developed COVID-3D ().