Tumor Endothelial Cells
Tumor Endothelial Cells
复制标题
DOI：
10.1101/cshperspect.a006536
复制
发表时间：
2012-03-01
影响因子：
5.4
通讯作者：
Dudley, Andrew C.
中科院分区：
文献类型：
--
作者：
Dudley, Andrew C.
血管内皮是一个动态的细胞“器官”，控制营养物质进入组织、维持血液流动并调节白细胞的运输。在肿瘤中，诸如缺氧和慢性生长因子刺激的因素导致内皮功能障碍。例如，肿瘤血管的直径不规则;它们是脆弱的，渗漏的，并且血流是异常的。现在有很好的证据表明，这些异常的肿瘤内皮细胞有助于肿瘤的生长和转移。因此，确定这些异常的生物学基础是至关重要的了解肿瘤进展的病理生理学和促进有效的抗血管生成治疗的设计和交付。
The vascular endothelium is a dynamic cellular "organ" that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction. For example, tumor blood vessels have irregular diameters; they are fragile, leaky, and blood flow is abnormal. There is now good evidence that these abnormalities in the tumor endothelium contribute to tumor growth and metastasis. Thus, determining the biological basis underlying these abnormalities is critical for understanding the pathophysiology of tumor progression and facilitating the design and delivery of effective antiangiogenic therapies.