Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
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DOI：
10.1038/nm0397-320
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发表时间：
1997-03-01
期刊：
影响因子：
82.9
通讯作者：
Bucala, R
中科院分区：
文献类型：
--
作者：
Donnelly, SC;Haslett, C;Bucala, R
迁移抑制因子（Migration Inhibitory Factor，MIF）具有显著的促炎作用，并有可能超越糖皮质激素的抗炎作用。在这项研究中，我们已经确定了显着数量的MIF在肺泡气室的急性呼吸窘迫综合征（ARDS）患者。我们发现，在ARDS患者的肺泡细胞中，MIF增加促炎细胞因子（TNF α和IL-8）的分泌，抗MIF显著减弱TNF α和IL-8的分泌，并且MIF以浓度相关的方式超越糖皮质激素的抗炎作用。这些结果表明，MIF可能作为一个调解人维持肺炎症反应在ARDS和抗MIF的策略可能代表一种新的治疗方法，在炎症性疾病，如ARDS。
Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.