Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord.
Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord.
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Cdk5 选择性地影响发育中的脊髓中不同神经元群的迁移。
DOI：
10.1002/cne.21377
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Yip,JosephW
中科院分区：
文献类型：
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作者：
Yip,YeePing;Capriotti,Christine;Drill,Emily;Tsai,Li-Huei;Yip,JosephW
研究表明，细胞周期蛋白依赖性激酶5（Cdk 5）对脑中神经元的迁移和存活至关重要。然而，Cdk 5在脊髓神经元迁移中的作用从未被研究过。本研究首次表明Cdk 5影响发育中脊髓中不同神经元群体的迁移。在没有Cdk 5的情况下，至少有四个神经元群体未能迁移到它们的最终目的地：交感神经节前神经元和副交感神经节前神经元，以及背侧起源和腹侧起源（U形组）的心肌黄酶阳性背角中间神经元。与此相反，迁移的躯体运动神经元和各种类型的腹侧和背侧的中间神经元不受Cdk 5的情况。此外，我们的研究结果表明，脊髓发育中依赖Cdk 5的迁移是轴突或胶质纤维介导的。最后，我们的研究结果表明，Cdk 5缺陷小鼠的交感节前神经元和躯体运动神经元继续延伸过程并向其正常靶区域投射，这表明Cdk 5对这两个神经元群体的轴突生长和脊髓发育的指导机制没有明显影响。神经学比较杂志503：297-307，2007.© 2007 Wiley利斯公司
It has been shown that cyclin‐dependent kinase 5 (Cdk5) is crucial for neuronal migration and survival in the brain. However, the role of Cdk5 in neuronal migration in the spinal cord has never been investigated. The present study is the first to show that Cdk5 affects the migration of different populations of neurons in the developing spinal cord. In the absence of Cdk5, at least four neuronal populations failed to migrate to their final destinations: sympathetic and parasympathetic preganglionic neurons, as well as dorsally originating and ventrally originating (U‐shaped group) diaphorase‐positive dorsal horn interneurons. In contrast, the migration of somatic motor neurons and various types of ventral and dorsal interneurons was unaffected by the absence of Cdk5. Moreover, our results suggest that Cdk5‐dependent migration in the developing spinal cord is axon‐ or glial fiber‐mediated. Finally, our results show that sympathetic preganglionic neurons and somatic motor neurons in Cdk5‐deficient mice continue to extend processes and project toward their normal target areas, suggesting that Cdk5 has no obvious effects on axonal outgrowth and guidance mechanisms of these two neuronal populations in spinal cord development. J. Comp. Neurol. 503:297–307, 2007. © 2007 Wiley‐Liss, Inc.