Observations on the carbohydrate metabolism of tumours.
Observations on the carbohydrate metabolism of tumours.
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DOI：
10.1042/bj0230536
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发表时间：
1929-01-01
影响因子：
4.1
通讯作者：
Crabtree, HG
中科院分区：
文献类型：
--
作者：
Crabtree, HG
在所引用的肿瘤中均发现U为阳性。有氧糖酵解不是肿瘤组织的特异性特征。瓦尔堡[1929]最近总结了正常组织具有有氧糖酵解的例子，Crabtree [1928]表明这是与细胞内病毒相关的某些病理过度生长的特性。在过去的一年里，随着材料的获得，我们测量了在本实验室繁殖的几种可移植小鼠肿瘤的碳水化合物代谢，结果列于表I。虽然瓦尔堡不再坚持以U的正值或负值为基础对组织进行分类，但在本通讯中，该值将被引入，作为提供任意比较的标准，使目前的测量结果与先前记录的测量结果保持一致。压力测量技术阐述了瓦尔堡一直遵循整个。
Positive values for Uwere invariably found for the tumours quoted. Aerobic glycolysis isnot a specific feature of tumour tissue. Warburg [1929] has recently summarised examples of normal tissues possessing aerobic glycolysis, and Crabtree [1928] showed it to be a property of certain patho-logical overgrowths associated with intracellular viruses. During the last year, as material has become available, the carbohydrate metabolism of several strains of transplantable mouse tumours, propagated in this laboratory, has been measured, and the results are collected in Table I. Although Warburg no longer adheres to the classification of tissues on the basis of a positive or negative value of U, throughout this communication the value will be introduced as affording an arbitrary standard of comparison, placing the present measurements in line with those previously recorded. The manometric technique elaborated by Warburg has been followed throughout.