Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome
Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome
复制标题
DOI：
10.1001/archneur.63.4.562
复制
发表时间：
2006-04-01
影响因子：
--
通讯作者：
Laureys, S
中科院分区：
文献类型：
--
作者：
Perrin, F;Schnakers, C;Laureys, S
背景：管理意识状态改变的严重脑损伤患者的一个主要挑战是估计他们对环境的残余感知。目的：调查行为记录良好的植物人状态（VS）患者、最低意识状态（MCS）患者和锁定综合征患者检测自己姓名的完整性。设计：我们记录了患者自己姓名和其他 7 个可能名字的听觉诱发电位。 15 名脑损伤患者。结果：在所有闭锁综合征患者、所有 MCS 患者以及 VS 中 5 名患者中的 3 名中，观察到 P3 成分对患者姓名的反应。与健康志愿者相比，MCS 和 VS 患者的 P3 潜伏期显着延迟 (P < .05)。 结论：这些结果表明，在非交流性脑损伤患者中可以观察到部分保留的语义处理，特别是在显着刺激的检测方面，例如受试者自己的名字。该功能在 MCS 和 VS 患者（如果存在）中似乎延迟。更重要的是，P3 反应不一定反映有意识的感知，并且不能用于区分 VS 和 MCS 患者。
Background: A major challenge in the management of severely brain-injured patients with altered states of consciousness is to estimate their residual perception of the environment.Objective: To investigate the integrity of detection of one's own name in patients in a behaviorally well-documented vegetative state (VS), patients in a minimally conscious state (MCS), and patients with locked-in syndrome.Design: We recorded the auditory evoked potentials to the patient's own name and to 7 other equiprobable first names in 15 brain-damaged patients.Results: A P3 component was observed in response to the patient's name in all patients with locked-in syndrome, in all MCS patients, and in 3 of 5 patients in a VS. P3 latency was significantly (P < .05) delayed for MCS and VS patients compared with healthy volunteers.Conclusions: These results suggest that partially preserved semantic processing could be observed in noncommunicative brain-damaged patients, notably for the detection of salient stimuli, such as the subject's own name. This function seems delayed in MCS and (if present) in VS patients. More important, a P3 response does not necessarily reflect conscious perception and cannot be used to differentiate VS from MCS patients.