Exosomes in immunoregulation of chronic lung diseases.
Exosomes in immunoregulation of chronic lung diseases.
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DOI：
10.1111/all.13086
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发表时间：
2017-04
期刊：
影响因子：
12.4
通讯作者：
Deshane JS
中科院分区：
文献类型：
--
作者：
Hough KP;Chanda D;Duncan SR;Thannickal VJ;Deshane JS
外泌体是从细胞中释放出来的纳米大小的膜结合囊泡，作为细胞间通信的一种形式，在细胞之间运输包括DNA、RNA和蛋白质在内的货物。除了它们在细胞间通讯中的作用外，外泌体开始被认为是免疫调节剂，可以调节抗原呈递、免疫激活、抑制和监视。本文总结了外泌体的这些多方面功能如何促进慢性炎症性肺部疾病的发生和/或进展，包括哮喘、慢性阻塞性肺疾病和肺纤维化。外泌体作为一种新的治疗方法的潜力也进行了讨论。
Exosomes are nano-sized, membrane-bound vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as a form of intercellular communication. In addition to their role in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation, immune activation, suppression and surveillance. This article summarizes how these multifaceted functions of exosomes may promote development and/or progression of chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. The potential of exosomes as a novel therapeutic are also discussed.