Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank.
Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank.
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DOI：
10.1097/pr9.0000000000001066
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发表时间：
2023-03
期刊：
影响因子：
4.8
通讯作者：
Smith BH
中科院分区：
文献类型：
--
作者：
Baskozos G;Hébert HL;Pascal MM;Themistocleous AC;Macfarlane GJ;Wynick D;Bennett DL;Smith BH
文本中提供了补充数字内容。对完成详细疼痛调查问卷的英国生物银行参与者进行的分析确定了与神经性疼痛 (NeuP) 与无慢性疼痛和非 NeuP 相关的因素，并估计了 NeuP 的患病率。先前对神经性疼痛的流行病学研究报告了一系列与该疾病相关的患病率和因素。本研究旨在在英国大型队列中验证这些特征。对 148,828 名完成慢性疼痛详细调查问卷的英国生物银行参与者进行了横断面分析。 Douleur Neuropathique en Quatre Questions (DN4) 用于区分疼痛持续时间至少 3 个月的参与者的神经性疼痛 (NeuP) 和非神经性疼痛 (non-NeuP)。参与者还被确定疼痛时间少于 3 个月或无疼痛 (NoCP)。使用多变量回归来分别识别与 NeuP 与非 NeuP 和 NoCP 相关的因素。 76,095 名参与者 (51.1%) 存在慢性疼痛。 NeuP 的总体患病率为 9.2%。与 NoCP 相比，神经性疼痛与健康相关生活质量较差、从事体力或个人服务类型职业以及年龄较小显着相关。正如预期的那样，NeuP 与糖尿病和神经病变有关，但也与其他疼痛（盆腔疼痛、术后疼痛和偏头痛）和肌肉骨骼疾病（类风湿性关节炎、骨关节炎和纤维肌痛）有关。此外，与非 NeuP 相比，NeuP 与四肢疼痛相关，并且疼痛强度更大，体重指数更高。与 NoCP 相比，女性与 NeuP 相关，而与非 NeuP 相比，男性与 NeuP 相关。这是迄今为止最大规模的神经性疼痛流行病学研究。结果证实，这种疾病在病因复杂的中老年人群中很常见，并且与非神经性疼痛相比，对健康的影响更大。
Supplemental Digital Content is Available in the Text. An analysis of UK Biobank participants who completed a detailed pain questionnaire identified factors associated with neuropathic pain (NeuP) vs no chronic pain and non-NeuP and estimated the prevalence of NeuP. Previous epidemiological studies of neuropathic pain have reported a range of prevalences and factors associated with the disorder. This study aimed to verify these characteristics in a large UK cohort. A cross-sectional analysis was conducted of 148,828 UK Biobank participants who completed a detailed questionnaire on chronic pain. The Douleur Neuropathique en Quatre Questions (DN4) was used to distinguish between neuropathic pain (NeuP) and non-neuropathic pain (non-NeuP) in participants with pain of at least 3 months' duration. Participants were also identified with less than 3 months' pain or without pain (NoCP). Multivariable regression was used to identify factors associated with NeuP compared with non-NeuP and NoCP, respectively. Chronic pain was present in 76,095 participants (51.1%). The overall prevalence of NeuP was 9.2%. Neuropathic pain was significantly associated with worse health-related quality of life, having a manual or personal service type occupation, and younger age compared with NoCP. As expected, NeuP was associated with diabetes and neuropathy, but also other pains (pelvic, postsurgical, and migraine) and musculoskeletal disorders (rheumatoid arthritis, osteoarthritis, and fibromyalgia). In addition, NeuP was associated with pain in the limbs and greater pain intensity and higher body mass index compared with non-NeuP. Female sex was associated with NeuP when compared with NoCP, whereas male sex was associated with NeuP when compared with non-NeuP. This is the largest epidemiological study of neuropathic pain to date. The results confirm that the disorder is common in a population of middle- to older-aged people with mixed aetiologies and is associated with a higher health impact than non-neuropathic pain.