Lifting the mask on neurological manifestations of COVID-19
Lifting the mask on neurological manifestations of COVID-19
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DOI：
10.1038/s41582-020-0398-3
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发表时间：
2020-08-24
影响因子：
38.1
通讯作者：
Padovani, Alessandro
中科院分区：
文献类型：
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作者：
Pezzini, Alessandro;Padovani, Alessandro
随着严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）疫情的蔓延，越来越明显的是，2019年冠状病毒病（COVID-19）不仅限于呼吸系统，其他器官也可能受到影响。特别是，在科学文献中越来越多地报道了与病毒有关的神经系统表现。在本文中，我们回顾了关于COVID-19与神经系统表现之间关系的文献，提出了临床前研究证据，表明SARS-CoV-2可能是许多这些表现的原因，并总结了可能构成每种神经系统症状的生物学途径。了解导致COVID-19患者神经系统表现的机制，以及这些表现与临床结果的相关性，将有助于指导优化使用靶向治疗策略。在这一观点中，Pezzini和Padovani批评了COVID-19神经学表现的证据，包括流行病学、神经病理学和神经影像学数据，并强调需要进一步开展工作以确定SARS-CoV-2是否与这些症状有关。
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In particular, virus-related neurological manifestations are being reported more and more frequently in the scientific literature. In this article, we review the literature on the association between COVID-19 and neurological manifestations, present evidence from preclinical research suggesting that SARS-CoV-2 could be responsible for many of these manifestations, and summarize the biological pathways that could underlie each neurological symptom. Understanding the mechanisms that lead to neurological manifestations in patients with COVID-19 and how these manifestations correlate with clinical outcomes will be instrumental in guiding the optimal use of targeted therapeutic strategies.In this Perspective, Pezzini and Padovani critique the evidence for neurological manifestations of COVID-19, including epidemiological, neuropathological and neuroimaging data, and highlight the need for further work to establish whether SARS-CoV-2 is responsible for these symptoms.