Effect of aging on power output properties in rat skinned cardiac myocytes.
Effect of aging on power output properties in rat skinned cardiac myocytes.
复制标题
衰老对大鼠皮心肌细胞功率输出特性的影响。
DOI：
10.1093/gerona/glr150
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Diffee,GaryM
中科院分区：
文献类型：
--
作者：
Chung,Eunhee;Diffee,GaryM
Aging is generally associated with a decline in several indices of cardiac function. The cellular mechanisms for this decline are not completely understood. The ability of the myocardium to perform external work (power output) is a critical aspect of ventricular function. The purpose of this study was to determine the effect of aging on loaded shortening and power output properties. We measured force–velocity properties in permeabilized (skinned) myocytes from the hearts of 9-, 24-, and 33-month-old male Fisher 344 × Brown Norway F1hybrid rats (F344BN) during loaded contractions using a force-clamp technique. Power output was calculated by multiplying force and shortening velocity values. We found that peak power output normalized to maximal force was significantly decreased by 18% and 31% in myocytes from 24- and 33-month-old group, respectively, compared with 9-month group (p< .05). These results suggest that aging is associated with a significant decrease in the ability of the myocardium to do work.
