Seizures in Fragile X Syndrome: Characteristics and Comorbid Diagnoses
Seizures in Fragile X Syndrome: Characteristics and Comorbid Diagnoses
复制标题
DOI：
10.1352/1944-7558-115.6.461
复制
发表时间：
2010-11-01
影响因子：
2.1
通讯作者：
Bailey, Donald B., Jr.
中科院分区：
文献类型：
--
作者：
Berry-Kravis, Elizabeth;Raspa, Melissa;Bailey, Donald B., Jr.
对脆性X综合征患者的照顾者进行的一项全国性调查涉及癫痫的特征和共同发生的情况。（1,090名男性和304名女性），14%的男性和6%的女性报告了癫痫发作。在一个大型脆性X综合征患者临床队列的病历回顾数据中发现了类似的特征和模式。国家调查数据显示，自闭症与癫痫发作显著相关，尽管脆性X综合征的癫痫发作通常不严重，也不容易用药物治疗，但它们似乎与影响功能的发育行为共病有关
A national survey of caregivers of individuals with fragile X syndrome addressed characteristics of epilepsy and co-occurring conditions Of the 1,394 individuals (1,090 males and 304 females) with the full mutation, 14% of males and 6% of females reported seizures Seizures were more often partial, began between ages 4 and 10 years, and were infrequent and easily treated Similar characteristics and patterns were seen in medical chart review data from a large clinic cohort of patients with fragile X syndrome National survey data showed that autism was significantly associated with seizures as a co-occurring condition Although seizures in fragile X syndrome are typically not severe and easily treated with medications, they appear to be associated with developmental-behavioral comorbidity that impacts function