Tumor therapy with targeted atomic nanogenerators
Tumor therapy with targeted atomic nanogenerators
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DOI：
10.1126/science.1064126
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发表时间：
2001-11-16
期刊：
影响因子：
56.9
通讯作者：
Scheinberg, DA
中科院分区：
文献类型：
--
作者：
McDevitt, MR;Ma, DS;Scheinberg, DA
单个高线性能量转移α粒子可以杀死靶细胞。我们已经开发出方法，使用锕-225偶联内化单克隆抗体，将分子大小的α发射同位素级联发生器靶向癌细胞内部。在体外，这些构建体在贝克勒尔（皮居里）水平特异性地杀死白血病、淋巴瘤、乳腺癌、卵巢癌、神经母细胞瘤和前列腺癌细胞。将单剂量的构建体以奈奎雷（nanocurie）水平注射到携带实体前列腺癌或播散性人淋巴瘤的小鼠中，在相当大一部分动物中诱导肿瘤消退和延长存活，而没有毒性。针对各种癌症的纳米发电机可能是可能的。
A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.