DEHYDROEPIANDROSTERONE - ANTIGLUCOCORTICOID ACTION IN MICE
DEHYDROEPIANDROSTERONE - ANTIGLUCOCORTICOID ACTION IN MICE
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DOI：
10.1097/00000441-199206000-00003
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发表时间：
1992-06-01
影响因子：
3.1
通讯作者：
SVEC, F
中科院分区：
文献类型：
--
作者：
BROWNE, ES;WRIGHT, BE;SVEC, F
使用雄性 Swiss-Webster 小鼠体内测试了脱氢表雄酮 (DHEA) 及其缀合物 DHEA-硫酸盐 (DHEA-S) 对糖皮质激素作用的急性影响。 作者发现 DHEA 和 DHEA-S 显着抑制肝脏酪氨酸转氨酶活性的诱导，尽管前者更有效。 这种抑制作用是剂量和时间依赖性的，并且用其他类固醇无法证明。 DHEA 对肾脏酪氨酸转氨酶诱导以及肝脏和肾脏鸟氨酸脱羧酶（另一种糖皮质激素诱导的酶）活性也有相同的抑制作用。 结论是 DHEA 具有强烈的抗糖皮质激素作用，并在不同的糖皮质激素敏感系统中发挥作用。
The acute effect of dehydroepiandrosterone (DHEA) and its conjugate, DHEA-sulfate (DHEA-S) on glucocorticoid action was tested in vivo using male Swiss-Webster mice. The authors found that DHEA and DHEA-S significantly inhibited induction of hepatic tyrosine aminotransferase activity, although the former was more potent. This inhibition was dose- and time-dependent and was not demonstrable with other steroids. The same inhibitory effect of DHEA was seen with kidney tyrosine aminotransferase induction, as well as with liver and kidney ornithine decarboxylase enzyme activity, another glucocorticoid-induced enzyme. The conclusion is that DHEA acts acutely as an antiglucocorticoid and exerts its effect in different glucocorticoid-sensitive systems.