S-oxalylglutathione is a substrate for gamma-glutamyltransferase (GGT). Implications for the role of GGT in cell proliferation.
S-oxalylglutathione is a substrate for gamma-glutamyltransferase (GGT). Implications for the role of GGT in cell proliferation.
复制标题
S-草酰谷胱甘肽是 γ-谷氨酰转移酶 (GGT) 的底物。
DOI：
10.1016/0006-291x(88)90466-4
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发表时间：
1988
影响因子：
3.1
通讯作者：
Skorczynski,SS
中科院分区：
文献类型：
--
作者：
Hamilton,GA;Buckthal,DJ;Kantorczyk,NJ;Skorczynski,SS
牛肾γ-谷氨酰转移酶以甘氨酸或水为受体，催化已知哺乳动物代谢物s -草酰谷胱甘肽的反应，其速度可与L-γ-谷氨酰对硝基苯胺（一种已知的良好底物）相当。n -草酰半胱氨酸甘氨酸是前一反应的最终产物。由于草酰硫酯是重要的细胞增殖抑制剂，因此提出该反应在控制细胞增殖中起主要作用。
With glycylglycine or water as acceptor, bovine kidney γ-glutamyltransferase catalyzes reactions of the known mammalian metabolite, S-oxalylglutathione, at rates comparable to those of L-γ-glutamyl-p-nitroanilide, a known good substrate. N-Oxalylcysteinylglycine is the eventual product of the former reaction. Since oxalyl thiolesters are implicated as important cell proliferation inhibitors, it is proposed that this reaction plays a major role in controlling cell proliferation.