A Longitudinal Twin Study on the Association Between Inattentive and Hyperactive-Impulsive ADHD Symptoms
A Longitudinal Twin Study on the Association Between Inattentive and Hyperactive-Impulsive ADHD Symptoms
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DOI：
10.1007/s10802-011-9513-7
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发表时间：
2011-07-01
影响因子：
3.6
通讯作者：
Plomin, Robert
中科院分区：
文献类型：
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作者：
Greven, Corina U.;Asherson, Philip;Plomin, Robert
DSM-IV区分了注意缺陷多动障碍（ADHD）的两个症状域：注意力不集中和多动冲动。本研究基于来自英国约7000对双胞胎的代表性人群样本，随着时间的推移，研究了注意力不集中和多动冲动之间关联的病因学和发展关系。使用Conners父母评定量表中的DSM-IV项目对两个年龄阶段的ADHD症状进行连续维度评估：儿童中期（1岁）和青春期早期（2岁）。定量遗传交叉滞后分析表明，ADHD各维度随时间的关联受到稳定和新出现的遗传因素的影响。此外，ADHD各维度之间的纵向关系似乎是单向的，童年中期的多动-冲动预示着青春期早期注意力不集中的存在，反之则不然。因此，随着时间的推移，过度活跃-冲动可能会加剧注意力不集中。研究结果在ADHD症状的发育变化的背景下进行了讨论。
DSM-IV distinguishes two symptom domains of attention deficit hyperactivity disorder (ADHD): inattentiveness and hyperactivity-impulsivity. The present study examines the aetiologies and developmental relations underlying the associations between inattentiveness and hyperactivity-impulsivity over time, based on a representative population sample from the United Kingdom of approximately 7,000 twin pairs. ADHD symptoms were assessed as continuous dimensions using the DSM-IV items from the Conners' Parent Rating Scale at two ages: middle childhood (age 1) and early adolescence (age 2). Quantitative genetic cross-lagged analyses showed that the association of the ADHD dimensions over time is influenced by stable as well as newly developing genetic factors. Moreover the longitudinal relationship between the ADHD dimensions appears to be unidirectional, with hyperactivity-impulsivity in middle childhood predicting the presence of inattentiveness in early adolescence, but not vice versa. Thus, hyperactivity-impulsivity may serve to exacerbate inattentiveness over time. Findings are discussed in the context of developmental changes in ADHD symptoms.