The neurobiology of conditioned and unconditioned fear: a neurobehavioral system analysis of the amygdala.
The neurobiology of conditioned and unconditioned fear: a neurobehavioral system analysis of the amygdala.
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DOI：
10.1177/1534582304265945
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Rosen, Jeffrey B
中科院分区：
文献类型：
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作者：
Rosen, Jeffrey B
一个神经行为系统的方法，条件和无条件的恐惧。通过在巴甫洛夫条件反射和无条件恐惧范式中采用可再现的恐惧行为，已经有可能描绘出条件反射和无条件恐惧在神经回路和细胞生物学上的一些差异。这表明杏仁核的基底外侧复合体和杏仁核的中央核是恐惧条件反射的神经回路的一部分，但不是对捕食者气味的无条件恐惧。此外，杏仁核外侧核中的转录因子早期生长反应基因1的表达的变化被证明是重要的上下文恐惧条件反射，但不是无条件的恐惧，捕食者的气味。此外，数据表明，虽然空调合成的捕食者气味，三甲基噻唑啉，一直难以证明，空调可以通过修改环境发生。最后，对人类焦虑症的动物研究的相关性进行了讨论。
A neurobehavioral system approach to conditioned and unconditioned fear is presented. By employing reproducible fear behaviors in Pavlovian conditioning and unconditioned fear paradigms, it has been possible to delineate some differences in neural circuitry and cellular biology for conditioned and unconditioned fear. It is suggested that the basolateral complex of the amygdala and the central nucleus of the amygdala are part of the neural circuitry for fear conditioning but not for unconditioned fear to a predator odor. Furthermore, changes in expression of the transcription factor early growth response gene 1 in the lateral nucleus of the amygdala are shown to be important for contextual fear conditioning but not for unconditioned fear to a predator odor. In addition, data suggest that although conditioning to a synthetic predator odor, trimethylthiazoline, has been difficult to demonstrate, conditioning can occur by modifying by the environment. Finally, the relevance of the animal studies to human anxiety disorders is discussed.