How do malaria ookinetes cross the mosquito midgut wall?
How do malaria ookinetes cross the mosquito midgut wall?
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DOI：
10.1016/j.pt.2004.11.001
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发表时间：
2005-01-01
影响因子：
9.6
通讯作者：
Ranford-Cartwright, LC
中科院分区：
文献类型：
--
作者：
Baton, LA;Ranford-Cartwright, LC
疟疾动合子穿过蚊子媒介的中肠壁所采取的路线一直（并将继续）有争议。在这篇文章中，我们试图重新解释和整合过去的明显相互矛盾的意见，使用最近提出的时间炸弹模型作为统一的框架。我们认为，寄生虫进入midguit上皮细胞总是细胞内，发生在多个相邻的宿主细胞会聚的网站，寄生虫退出中肠上皮细胞可以发生细胞内或细胞间的路线，这取决于入侵的宿主细胞被挤出中肠壁的方式。我们还提出了一个新的假说，细胞跑步机模型，来解释运动的动合子通过多个相邻的中肠细胞。
The route taken by malaria ookinetes to cross the midgut wall of the mosquito vector has been (and continues to be) controversial. In this article, we attempt to reinterpret and integrate the apparently conflicting observations of the past using the recently proposed Time Bomb model of ookinete invasion as a unifying framework. We argue that parasite entry into the midguit epithelium is always intracellular, occurs at sites where multiple adjacent host cells converge, and that parasite exit from the midgut epithelium can occur by either an intracellular or intercellular route, depending on the manner in which invaded host cells are extruded from the midgut wall. We also propose a novel hypothesis, the Cellular Treadmill model, to explain the movement of ookinetes through multiple adjacent midgut cells.