A Preliminary Feasibility Study of Varenicline for Smoking Cessation in Bipolar Disorder.
A Preliminary Feasibility Study of Varenicline for Smoking Cessation in Bipolar Disorder.
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伐尼克兰用于双相情感障碍戒烟的初步可行性研究。
DOI：
10.1080/15504263.2012.671067
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发表时间：
2012
影响因子：
2.2
通讯作者：
George,TonyP
中科院分区：
文献类型：
--
作者：
Wu,BeckyS;Weinberger,AndreaH;Mancuso,Enza;Wing,VictoriaC;Haji-Khamneh,Bahar;Levinson,AndreaJ;George,TonyP
我们对双相情感障碍患者戒烟干预措施的研究回顾（George、Wu 和 Weinberger，2012 年，本期）表明这些患者需要安全有效的戒烟治疗。迄今为止，仅发表了一项研究：对 5 名双相情感障碍吸烟者进行的试验，用缓释 (SR) 安非他酮治疗（Weinberger 等人，2008 年）显示出该群体的烟草治疗前景。伐尼克兰是最新 FDA 批准的治疗烟草成瘾的一线药物。伐尼克兰是烟碱乙酰胆碱受体 α4β2 亚型的部分激动剂（Nides，2008），可能比安非他酮 SR 更有效（Gonzales 等，2006）。虽然伐尼克兰具有普遍可接受的安全性，但上市后报告中已经出现了神经精神症状，包括情绪改变、攻击性和精神病（Kohen & Kremen，2007；Tonstad、Davies、Flammer、Russ 和 Hughes，2010）。因此，当前试点研究的目的是调查伐尼克兰对患有双相情感障碍的吸烟者的安全性和有效性。采用双盲、随机、安慰剂对照 10 周设计，对尼古丁依赖型双相情感障碍吸烟者进行了随机分组
Our review of studies examining smoking cessation interventions among persons with bipolar disorders (George, Wu, & Weinberger, 2012, this issue) shows the need for safe and efficacious smoking cessation treatments for these patients. Only one study has been published thus far: a trial of 5 bipolar smokers treated with sustained-release (SR) bupropion (Weinberger et al., 2008) showed promise for tobacco treatment in this group.Varenicline is the latest FDA-approved first-line pharmacotherapy for tobacco addiction. A partial agonist for the alpha4beta2 subtype of nicotinic acetylcholine receptors (Nides, 2008), varenicline may be more efficacious than bupropion SR (Gonzales et al., 2006). While varenicline has a generally acceptable safety profile, neuropsychiatric symptoms have emerged in post-marketing reports including mood alterations, aggression, and psychosis (Kohen & Kremen, 2007; Tonstad, Davies, Flammer, Russ, & Hughes, 2010). Therefore, the aim of the current pilot study was to investigate the safety and efficacy of varenicline in smokers with bipolar disorder. Using a double-blind, randomized, placebo-controlled 10-week design, nicotine-dependent bipolar smokers were ran-