Principles and Properties of Stress Granules.
Principles and Properties of Stress Granules.
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DOI：
10.1016/j.tcb.2016.05.004
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发表时间：
2016-09
影响因子：
19
通讯作者：
Parker R
中科院分区：
文献类型：
--
作者：
Protter DSW;Parker R
应激颗粒是由在翻译起始中停滞的mRNA形成的非翻译mRNP的组装体。应激颗粒通过将mRNP群体连接在一起的mRNA结合蛋白之间的相互作用形成。促进应激颗粒形成的相互作用包括常规的蛋白质-蛋白质相互作用，以及涉及蛋白质的固有无序区域的相互作用。应激颗粒的组装和分解受到多种翻译后修饰以及许多ATP依赖性RNP或蛋白质重塑复合物的调节，说明应激颗粒代表活性液体，其中能量输入维持其动态状态。应激颗粒的形成调节应激反应、病毒感染和信号通路。持续或异常的应激颗粒形成有助于神经退行性疾病和某些癌症。
Stress granules are assemblies of untranslating mRNPs that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions, as well as interactions involving intrinsically disordered regions of proteins. Assembly and disassembly of stress granules are modulated by a variety of post-translational modifications as well as a number of ATP dependent RNP or protein remodeling complexes, illustrating that stress granules represent an active liquid wherein energy input maintains their dynamic state. Stress granule formation modulates the stress response, viral infection, and signaling pathways. Persistent or aberrant stress granule formation contributes to neurodegenerative disease and some cancers.