DIFFUSION AND RELAXATION MAPPING OF CARTILAGE-BONE PLUGS AND EXCISED DISKS USING MICROSCOPIC MAGNETIC-RESONANCE-IMAGING
DIFFUSION AND RELAXATION MAPPING OF CARTILAGE-BONE PLUGS AND EXCISED DISKS USING MICROSCOPIC MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1002/mrm.1910310306
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发表时间：
1994-03-01
影响因子：
3.3
通讯作者：
JELINSKI, LW
中科院分区：
文献类型：
--
作者：
XIA, Y;FARQUHAR, T;JELINSKI, LW
质子自扩散系数（D）和弛豫时间（T-1和T-2）的空间分辨地图上获得的软骨-骨塞样品和犬软骨切除的磁盘在30 μ m的横向分辨率，使用显微磁共振成像（micro-MRI）。结果进行了比较切除的软骨盘和完整的软骨-骨栓。报告了绝对水浓度、自扩散系数和T-1弛豫之间的相关性。扩散系数不是水浓度的线性函数。圆盘的厚度为600 μ m，与ca.对于软骨-骨栓观察到900 μ m，这可能是由于在前一样品中没有交叉指状软骨和骨的界面或潮标层。我们的研究结果表明，切除的软骨盘是关节面和前500微米左右组织的极好模型。自旋-自旋和自旋-晶格弛豫时间的分子参数，以及水的自扩散系数，在两种类型的样品中几乎是相同的。然而，软骨-骨栓具有允许研究潮标区域的附加特征，该区域可能在机械力的传递中起主要作用。
Spatially resolved maps of proton self-diffusion coefficients (D) and relaxation times (T-1 and T-2) were obtained on cartilage-bone plug samples and on excised disks of canine cartilage at a transverse resolution of 30 mu m, using microscopic magnetic resonance imaging (micro-MRI). Results are compared for excised disks of cartilage and intact cartilage-bone plugs. Correlations between the absolute water concentration, the self-diffusion coefficient and the T-1 relaxation are reported. The diffusion coefficient is not a linear function of water concentration. The thickness of the disks is 600 mu m, compared with the ca. 900 mu m observed for the cartilage-bone plugs, presumably due to the absence of the interfacial or tidemark layer of interdigitated cartilage and bone in the former samples. Our results suggest that excised disks of cartilage are excellent models for the articular surface and the first 500 or so microns of tissue. The molecular parameters of spin-spin and spin-lattice relaxation times, as well as the water self-diffusion coefficient, are virtually identical in the two types of samples. However, the cartilage-bone plugs have the additional feature of permitting the study of the tidemark region, a region that likely plays a major role in the transmission of mechanical force.