Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival.
Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival.
复制标题
晚期肝细胞癌：基于灌注计算机断层扫描的动力学参数作为预测患者生存的预后生物标志物。
DOI：
10.1097/rct.0000000000000288
复制
发表时间：
2015
影响因子：
1.3
通讯作者：
Yoshida,Hiroyuki
中科院分区：
文献类型：
--
作者：
Lee,SangHo;Hayano,Koichi;Zhu,AndrewX;Sahani,DushyantV;Yoshida,Hiroyuki
本研究的目的是寻找预后的生物标志物灌注计算机断层扫描（PCT）为基础的动力学参数为晚期肝细胞癌（HCC）治疗与antiangiogenic chemotherapy.MethodsTwenty-two晚期HCC患者进行PCT成像，随后接受贝伐单抗与吉西他滨和奥沙利铂的组合。使用Tofts-Kety、二室交换、组织均匀性绝热近似（AATH）和分布参数模型分析晚期HCC的治疗前PCT数据。计算血流量、血容量、提取分数（E）等3个参数。在每个模型中的动力学参数进行了评估，1年生存歧视使用Kaplan-Meier分析和总生存率使用单变量考克斯regression analysis.ResultsOnly的AATH模型衍生的E是统计学显著预后1年生存。AATH模型衍生的E增加与总生存期延长显著相关（P= 0.005）。
ObjectiveThe aim of this study was to find prognostic biomarkers in perfusion computed tomography (PCT)–based kinetic parameters for advanced hepatocellular carcinoma (HCC) treated with antiangiogenic chemotherapy.MethodsTwenty-two patients with advanced HCC underwent PCT imaging and subsequently received bevacizumab in combination with gemcitabine and oxaliplatin. Pretreatment PCT data within advanced HCC were analyzed using the Tofts-Kety, 2-compartment exchange, adiabatic approximation to the tissue homogeneity (AATH), and distributed parameter models. Blood flow, blood volume, extraction fraction (E), and other 3 parameters were calculated. Kinetic parameters in each model were evaluated with 1-year survival discrimination using Kaplan-Meier analysis and with overall survival using univariate Cox regression analysis.ResultsOnly the AATH model–derived E was statistically significantly prognostic for 1-year survival. The increased AATH model–derived E was significantly associated with longer overall survival (P= 0.005).Conclusions