Functional neuroimaging studies of prospective memory: What have we learnt so far?
Functional neuroimaging studies of prospective memory: What have we learnt so far?
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DOI：
10.1016/j.neuropsychologia.2011.02.014
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发表时间：
2011-07-01
期刊：
影响因子：
2.6
通讯作者：
Volle, Emmanuelle
中科院分区：
文献类型：
--
作者：
Burgess, Paul W.;Gonen-Yaacovi, Gil;Volle, Emmanuelle
“前瞻性记忆”一词所描述的行为的复杂性意味着，在进行最早的研究时，人们根本不清楚这是否会成为神经影像学研究的一个富有成果的领域。然而，头侧前额叶皮层（接近布罗德曼 10 区）的激活与前瞻性记忆范式的表现之间迅速出现了一致的关系。这种一致性极大地增加了研究结果的积累，因为每项研究都为之前的研究提供了观点。功能性神经影像学研究结果与其他方法（例如人类病变研究、电生理学）之间的广泛共识也提供了相当大的帮助。鉴于已进行的研究相对较少，这一结果已经取得了相当惊人的进展。对这些发现以及其他大脑区域的发现进行了总结，并提出了新的方向。关键点是前额皮质内部存在内侧-外侧分离。内侧前额皮质的一些（但不是全部）区域通常仅在执行正在进行的任务时更加活跃，而横向方面在涉及延迟意图的情况下相对更加活跃。其中一些前额皮质激活似乎对所呈现的刺激材料的形式、正在进行的任务的性质、意图的具体情况、检测 PM 线索的难易程度、或者回忆预期的行动非常不敏感。然而，前额叶皮层内的其他区域的血流动力学变化会随着前瞻性记忆范式的这些和其他方面的变化而变化。结论是，前额叶皮层很可能在创造、维持和实施延迟意图的许多阶段发挥着超级作用，在某些情况下，这可能与最近的证据表明该大脑区域参与控制刺激导向与刺激无关的关注有关。在前瞻性记忆范式中激活的其他关键大脑区域似乎是顶叶，特别是布罗德曼区 (BA) 40 和楔前叶 (BA 7)，以及前扣带回 (BA 32)。这些区域通常在广泛的任务中与外侧前额皮质共同激活，而不仅仅是涉及前瞻记忆的任务。 (C) 2011 年，爱思唯尔有限公司出版。
The complexity of the behaviour described by the term "prospective memory" meant that it was not at all clear, when the earliest studies were conducted, that this would prove a fruitful area for neuroimaging study. However, a consistent relation rapidly emerged between activation in rostral prefrontal cortex (approximating Brodmann Area 10) and performance of prospective memory paradigms. This consistency has greatly increased the accumulation of findings, since each study has offered perspectives on the previous ones. Considerable help too has come from broad agreement between functional neuroimaging findings and those from other methods (e.g. human lesion studies, electrophysiology). The result has been a quite startling degree of advance given the relatively few studies that have been conducted. These findings are summarised, along with those from other brain regions, and new directions suggested. Key points are that there is a medial-lateral dissociation within rostral PFC. Some (but not all) regions of medial rostral PFC are typically more active during performance of the ongoing task only, and lateral aspects are relatively more active during conditions involving delayed intentions. Some of these rostral PFC activations seem remarkably insensitive to the form of stimulus material presented, the nature of the ongoing task, the specifics of the intention, how easy or hard the PM cue is to detect, or the intended action is to recall. However there are other regions within rostral PFC where haemodynamic changes vary with alterations in these, and other, aspects of prospective memory paradigms. It is concluded that rostral PFC most likely plays a super-ordinate role during many stages of creating, maintaining and enacting delayed intentions, which in some cases may be linked to recent evidence showing that this brain region is involved in the control of stimulus-oriented vs. stimulus-independent attending. Other key brain regions activated during prospective memory paradigms appear to be the parietal lobe, especially Brodmann Area (BA) 40 and precuneus (BA 7), and the anterior cingulate (BA 32). These regions are often co-activated with lateral rostral PFC across a wide range of tasks, not just those involving prospective memory. (C) 2011 Published by Elsevier Ltd.