The role of 14-3-3 proteins in gynecological tumors.
The role of 14-3-3 proteins in gynecological tumors.
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DOI：
10.2741/4348
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
Wenwen Zhang;Q. Shen;Miaomiao Chen;Ying Wang;Qingfeng Zhou;Xuejiao Tao;Xueqiong Zhu
中科院分区：
文献类型：
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作者：
Wenwen Zhang;Q. Shen;Miaomiao Chen;Ying Wang;Qingfeng Zhou;Xuejiao Tao;Xueqiong Zhu
14-3-3蛋白是一个高度保守的细胞内蛋白家族，在细胞代谢、蛋白运输、信号转导、细胞凋亡和细胞周期调控等重要生理过程中发挥着重要作用。这些蛋白质参与各种肿瘤抑制基因和癌基因的调节，表明它们在人类癌症中的潜在作用。一些人认为，妇科肿瘤中的14-3-3蛋白会促进妇科肿瘤，而另一些人则认为14-3-3蛋白在此类肿瘤中充当肿瘤抑制因子。在此，我们综述了14-3-3蛋白作为妇科恶性肿瘤筛查和早期诊断的新标志物，以及在监测治疗效果方面的应用。14-3-3蛋白可作为肿瘤的预后因子和特异性靶点。
A large family of highly conserved cellular 14-3-3 proteins plays key roles in the regulation of central physiological pathways such as metabolism, protein trafficking, signal transduction, apoptosis and regulation of cell cycle. The involvement of these proteins in the regulation of various tumor suppressor genes and oncogenes points to their potential role in human cancer. According to some, the 14-3-3 proteins in gynecological tumors, promote gynecological tumors whereas others suggest that 14-3-3 proteins function as tumor suppressors in such tumors. Here, we review the use of 14-3-3 proteins as novel markers for screening and early diagnosis of gyncyological malignancies, and in monitoring the effectiveness of treatment. 14-3-3 proteins are proposed to be used as prognostic factors and as specific target in the treatment of cancers.