Cardio-Oncology: Understanding the Intersections Between Cardiac Metabolism and Cancer Biology.
Cardio-Oncology: Understanding the Intersections Between Cardiac Metabolism and Cancer Biology.
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DOI：
10.1016/j.jacbts.2021.05.008
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Ky B
中科院分区：
文献类型：
--
作者：
Karlstaedt A;Barrett M;Hu R;Gammons ST;Ky B
癌细胞可以促进心脏的代谢重塑。代谢变化为新的治疗策略提供了机会，以通过新的成像技术预防心力衰竭和监测疾病进展。需要转化生物标志物和成像研究来进一步了解癌细胞生物学对心脏的影响。肿瘤患者心血管护理的一个重要优先事项是降低发病率和死亡率，并通过跨学科的努力提高癌症幸存者的生活质量。在过去的几十年里，癌症患者的生存率有了显着提高。尽管如此，从长远来看，幸存者可能更有可能死于心血管疾病，不仅是癌症治疗的潜在毒性，而且是癌症的生物学。在这种情况下，基础和转化研究的努力对于理解癌症患者和幸存者心血管疾病的分子机制以及确定可能预防和治疗这两种疾病的新治疗靶点至关重要。这篇综述旨在强调我们目前对癌症和心脏之间代谢相互作用的理解，包括潜在的治疗靶点。还提供了可以支持研究和临床管理的成像技术的概述。最后，这次审查强调的机会和挑战，是必要的，以促进我们的代谢的背景下，心脏肿瘤学的理解。
Cancer cells can promote metabolic remodeling in the heart. Metabolic changes provide opportunities for novel treatment strategies to prevent heart failure and monitor disease progression through new imaging techniques. Translational biomarker and imaging studies are needed to further understand the impact of cancer cell biology on the heart. An important priority in the cardiovascular care of oncology patients is to reduce morbidity and mortality, and improve the quality of life in cancer survivors through cross-disciplinary efforts. The rate of survival in cancer patients has improved dramatically over the past decades. Nonetheless, survivors may be more likely to die from cardiovascular disease in the long term, secondary, not only to the potential toxicity of cancer therapeutics, but also to the biology of cancer. In this context, efforts from basic and translational studies are crucial to understanding the molecular mechanisms causal to cardiovascular disease in cancer patients and survivors, and identifying new therapeutic targets that may prevent and treat both diseases. This review aims to highlight our current understanding of the metabolic interaction between cancer and the heart, including potential therapeutic targets. An overview of imaging techniques that can support both research studies and clinical management is also provided. Finally, this review highlights opportunities and challenges that are necessary to advance our understanding of metabolism in the context of cardio-oncology.
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影响因子：
3.4
作者：
EHRENBERG, B;MONTANA, V;LOEW, LM
通讯作者：
LOEW, LM
影响因子：
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158.5
作者：
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影响因子：
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作者：
ALLARD, MF;SCHONEKESS, BO;LOPASCHUK, GD
通讯作者：
LOPASCHUK, GD
DOI：
10.1016/s0735-1097(02)01967-8
发表时间：
2002-07-17
影响因子：
24
作者：
Dávila-Román, VG;Vedala, G;Gropler, RJ
通讯作者：
Gropler, RJ