Serotonergic modulation of psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field
Serotonergic modulation of psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field
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DOI：
10.1016/j.brainres.2004.06.078
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发表时间：
2004-10
期刊：
影响因子：
2.9
通讯作者：
M. Matsumoto;H. Togashi;S. Ohashi;K. Tachibana;Taku Yamaguchi;M. Yoshioka
中科院分区：
文献类型：
--
作者：
M. Matsumoto;H. Togashi;S. Ohashi;K. Tachibana;Taku Yamaguchi;M. Yoshioka
为了阐明5-羟色胺能神经元系统在应激诱导的突触可塑性改变中的可能作用，用5，7-二羟色胺(5，7-DHT，200μg/只大鼠，i.c.v)预先处理5-羟色胺(5，7-DHT，200μg/只)，观察了情景恐惧条件对5-羟色胺耗竭大鼠海马区长时程增强的影响。足底电击(FS)可抑制5-羟色胺(5-HT)损毁大鼠和赋形剂对照组大鼠LTP的诱导。当大鼠暴露于刺激FS后24小时的CFC时，两个处理组的LTP也被阻断。然而，与对照组相比，5-羟色胺损毁组大鼠的LTP损伤明显减轻。在刺激FS后，两组大鼠的恐惧相关冰冻行为相似，而在5-羟色胺损伤的大鼠中，暴露于氟氯化碳期间观察到的行为显著减少。这些结果表明，5-羟色胺能机制参与了心理应激诱导的突触可塑性的改变，这似乎与恐惧相关的行为有关。
In order to elucidate possible involvement of the serotonergic neuronal system in the stress-induced alteration in synaptic plasticity, the effects of contextual fear conditioning (CFC) on long-term potentiation (LTP) in the hippocampal CA1 field were examined in 5-HT-depleted rats by pretreatment with 5,7-dihydroxytryptamine (5,7-DHT, 200 μg/rat, i.c.v.). LTP induction was suppressed by footshock (FS) stimulation in 5-HT-lesioned rats and vehicle-treated controls. When rats were exposed to CFC, which was received 24 h after FS stimulation, LTP was also blocked in both-treated groups. CFC-induced impairment of LTP, however, significantly attenuated in 5-HT-lesioned rats when compared with that in controls. Fear-related freezing behavior after FS stimulation occurred similarly in both treated groups, whereas the behavior observed during exposure to CFC significantly reduced in 5-HT-lesioned rats. These results suggest that the serotonergic mechanism is involved in the psychological stress-induced alteration in synaptic plasticity, which appears to be associated with fear-related behavior.