Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans
Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans
复制标题
DOI：
10.1152/ajpregu.00562.2010
复制
发表时间：
2011-07-01
影响因子：
2.8
通讯作者：
Fu, Qi
中科院分区：
文献类型：
--
作者：
Jarvis, Sara S.;VanGundy, Tiffany B.;Fu, Qi
Jarvis SS，VanGundy TB，Galbreath MM，柴田S，Okazaki K，Reelick MF，Levine BD，Fu Q.健康年轻人静态握力运动中血管交感神经流出调节的性别差异。Am J Physiol Regul Integr Comp Physiol 301：R193-R200，2011.首次发表于2011年4月20日; doi：10.1152/ajpregu.00562.2010.-人类静态运动中交感神经控制的性别差异很少，研究结果也不一致。我们假设女性对静态运动的血管交感神经反应会减弱，在高性激素[黄体中期（ML）]与低激素阶段[卵泡早期（EF）]之间会进一步降低。我们测量了心率（HR），血压（BP），和肌肉交感神经活动（MSNA）在11名女性和10名男性在冷加压试验（CPT）和静态握力疲劳与2分钟的运动后循环停止（PECA）。HR在握力过程中增加，在疲劳时达到峰值，并且在性别之间具有可比性。BP在握力和PECA期间增加，其中男性从基线增加较大。女性在握力和PECA期间的平均+/- SD MSNA爆发频率（BF）较低（EF，P < 0.05），Delta MSNA-BF较小（主效应，均P < 0.01）。疲劳时男性的Delta总活性较高（EF：632 +/- 418 vs. ML：598 +/- 342 vs.男性：1，025 +/- 416 a.u./分钟，EF和ML与男性相比P < 0.001）和PECA期间（EF：354 +/- 321 vs. ML：341 +/- 199 vs.男性：599 +/- 327 a.u./ EF和ML与男性相比，P < 0.05）。在CPT期间，HR和MSNA反应在性别和激素阶段之间相似，证实了中枢整合和交感神经传出通路在性别和激素阶段之间具有可比性。女性表现出迟钝的代谢反射，不受性激素的影响，这可能是由于肌肉质量或纤维类型的差异，因此，第四组传入的代谢刺激。
Jarvis SS, VanGundy TB, Galbreath MM, Shibata S, Okazaki K, Reelick MF, Levine BD, Fu Q. Sex differences in the modulation of vasomotor sympathetic outflow during static hand-grip exercise in healthy young humans. Am J Physiol Regul Integr Comp Physiol 301: R193-R200, 2011. First published April 20, 2011; doi:10.1152/ajpregu.00562.2010.-Sex differences in sympathetic neural control during static exercise in humans are few and the findings are inconsistent. We hypothesized women would have an attenuated vasomotor sympathetic response to static exercise, which would be further reduced during the high sex hormone [midluteal (ML)] vs. the low hormone phase [early follicular (EF)]. We measured heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) in 11 women and 10 men during a cold pressor test (CPT) and static handgrip to fatigue with 2 min of postexercise circulatory arrest (PECA). HR increased during handgrip, reached its peak at fatigue, and was comparable between sexes. BP increased during handgrip and PECA where men had larger increases from baseline. Mean +/- SD MSNA burst frequency (BF) during handgrip and PECA was lower in women (EF, P < 0.05), as was Delta MSNA-BF smaller (main effect, both P < 0.01). Delta Total activity was higher in men at fatigue (EF: 632 +/- 418 vs. ML: 598 +/- 342 vs. men: 1,025 +/- 416 a.u./min, P < 0.001 for EF and ML vs. men) and during PECA (EF: 354 +/- 321 vs. ML: 341 +/- 199 vs. men: 599 +/- 327 a.u./min, P < 0.05 for EF and ML vs. men). During CPT, HR and MSNA responses were similar between sexes and hormone phases, confirming that central integration and the sympathetic efferent pathway was comparable between the sexes and across hormone phases. Women demonstrated a blunted metaboreflex, unaffected by sex hormones, which may be due to differences in muscle mass or fiber type and, therefore, metabolic stimulation of group IV afferents.