A GENE ENCODING AN ANTIGEN RECOGNIZED BY CYTOLYTIC LYMPHOCYTES-T ON A HUMAN-MELANOMA
A GENE ENCODING AN ANTIGEN RECOGNIZED BY CYTOLYTIC LYMPHOCYTES-T ON A HUMAN-MELANOMA
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DOI：
10.1126/science.1840703
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发表时间：
1991-12-13
期刊：
影响因子：
56.9
通讯作者：
BOON, T
中科院分区：
文献类型：
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作者：
VANDERBRUGGEN, P;TRAVERSARI, C;BOON, T
许多人类黑色素瘤肿瘤表达的抗原在体外可被携带肿瘤患者的细胞溶解T淋巴细胞(CTL)识别。在一株人黑色素瘤细胞系上发现了一种基因，该基因可调控MZ2-E抗原的表达。该基因与已知序列没有相似性，属于一个至少有三个基因的家族。它由原始黑色素瘤细胞、其他黑色素瘤细胞系和一些其他组织类型的肿瘤细胞表达。在一组正常组织中没有观察到表达。抗原MZ2-E似乎是由人类白细胞抗原A1呈递的；原始患者的抗MZ2-E CTL识别其他人类白细胞抗原A1患者的两个黑色素瘤细胞系。因此，针对MZ2-E抗原的精确靶向免疫治疗可以提供给通过对小肿瘤样本的HLA配型和RNA分析而鉴定的个体。
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample.