Prior Herpes Simplex Virus Infection and the Risk of Herpes Zoster.
Prior Herpes Simplex Virus Infection and the Risk of Herpes Zoster.
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既往单纯疱疹病毒感染和带状疱疹风险。
DOI：
10.1093/infdis/jiad259
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Wald,Anna
中科院分区：
文献类型：
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作者：
Harbecke,Ruth;Oxman,MichaelN;Selke,Stacy;Ashbaugh,MarkE;Lan,KristineF;Koelle,DavidM;Wald,Anna
在美国，随着单纯疱疹病毒（HSV）感染率的下降，带状疱疹（HZ）的发病率也在上升。我们假设缺乏HSV引起的对水痘带状疱疹病毒（VZV）的交叉反应性免疫导致HZ风险增加。使用带状疱疹预防研究的安慰剂组的样本，我们研究了发展HZ的人是否比不发展HZ的人更不可能有先前的HSV感染，以及HSV患者中HZ的严重程度是否低于HSV血清阴性者。2）比较病例中HSV-1和HSV-2的血清阳性率的研究（聚合酶链反应证实的HZ患者）与年龄、性别、和健康匹配的对照组（人没有HZ）。结果血清从639名研究参与者（213例和426对照）产生了明确的HSV抗体结果，并进行了分析。总体而言，HSV血清阳性率为75%。HSV血清阴性的HZ病例显著高于对照组（30.5% vs 22.3%;P= 0.024），HSV血清阴性的HZ风险比HSV血清阳性的参与者高55%。HSV血清阳性与更严重的HZ（P= 0.021）。ConclusionsOur研究表明，以前感染HSV部分保护对HZ。
BackgroundThe incidence of herpes zoster (HZ) has increased in the United States concurrent with decrease in herpes simplex virus (HSV) prevalence. We hypothesized that lack of HSV-elicited cross-reactive immunity to varicella-zoster virus (VZV) results in an increased risk of HZ. Using specimens from the placebo arm of the Shingles Prevention Study, we investigated whether persons who develop HZ are less likely to have prior HSV infection than persons who do not develop HZ, and whether HZ is less severe in persons with HSV than in HSV seronegative persons.MethodsWe conducted a nested case-control (1:2) study comparing the seroprevalence of HSV-1 and HSV-2 in cases (persons with polymerase chain reaction-confirmed HZ) to age-, sex-, and health-matched controls (persons without HZ).ResultsSera from 639 study participants (213 cases and 426 controls) yielded definitive HSV antibody results and were analyzed. Overall, HSV seropositivity rate was 75%. HSV seronegativity was significantly higher in HZ cases than controls (30.5% vs 22.3%;P= .024), with a 55% higher risk of HZ in HSV seronegative than HSV seropositive participants. HSV seropositivity was associated with more severe HZ (P= .021).ConclusionsOur study demonstrated that prior infection with HSV partly protects against HZ.