RAPID METHOD FOR MEASUREMENT OF BRONCHIAL RESPONSIVENESS
RAPID METHOD FOR MEASUREMENT OF BRONCHIAL RESPONSIVENESS
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DOI：
10.1136/thx.38.10.760
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发表时间：
1983-01-01
期刊：
影响因子：
10
通讯作者：
WOOLCOCK, AJ
中科院分区：
文献类型：
--
作者：
YAN, K;SALOME, C;WOOLCOCK, AJ
本文介绍了一种快速、简便的测定支气管对吸入组胺反应性的方法。该方法被用来获得剂量反应曲线在50过敏性[哮喘和鼻炎]受试者不同的呼吸道和鼻腔症状。引起1秒用力呼气量（PD 20-FEV 1）下降20%的组胺的累积剂量在0.046 μ mol和大于3.9 μ mol之间变化，并且与症状的严重程度相关。PD 20-FEV 1的重现性，从重复测量15例不同程度的支气管反应性，是令人满意的。用本方法测定的PD_（20）-FEV_1与剂量计法测定的PD_（20）-FEV_1比较无显著性差异。
A rapid, simple method for measuring bronchial responsiveness to inhaled histamine is described. The method was used to obtain dose response curves in 50 atopic [asthma and rhinitis] subjects with varying respiratory and nasal symptoms. The cumulative dose of histamine which caused a 20% fall in the 1-s forced expiratory volume (PD20-FEV1) varied between 0.046 and greater than 3.9 .mu.mol and correlated with the severity of symptoms. The reproducibility of the PD20-FEV1, determined from duplicate measurements in 15 patients with varying degrees of bronchial responsiveness, was satisfactory. When the PD20-FEV1 from this rapid method was compared with that obtained from the dosimeter method, no significant difference was found. The dose delivered by this method was cumulative.