Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein
Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein
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DOI：
10.1159/000201441
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发表时间：
1997-03-01
期刊：
影响因子：
3.2
通讯作者：
Raknerud, N
中科院分区：
文献类型：
--
作者：
Roseth, AG;Aadland, E;Raknerud, N
本研究包括62例门诊溃疡性结肠炎患者，他们接受了64次结肠镜检查。根据内镜和组织学标准评价疾病活动性。结果显示，内镜以及疾病活动和粪便钙卫蛋白的组织学分级之间的显着相关性。对照组（6 mg/l）和无或低疾病活动性患者（11.5 mg/l）的粪便钙卫蛋白水平中位数存在显著差异（p < 0.0001）。活动性疾病患者的中位钙卫蛋白水平为68 mg/l，与后一组有显著差异（p < 0.0001）。此外，我们认为，炎症的程度，而不是疾病的程度决定了粪便钙卫蛋白水平。总之，粪便钙卫蛋白的评估似乎是溃疡性结肠炎患者疾病活动的标志物。
This study comprised 62 outpatients with ulcerative colitis who underwent 64 colonoscopies. The disease activity was evaluated according to endoscopic and histological criteria. The results revealed a significant correlation between both the endoscopic as well as the histological gradings of disease activity and faecal calprotectin. The median faecal calprotectin levels in the control group (6 mg/l) and in the patients with no or low disease activity (11.5 mg/l) were significantly different (p < 0.0001). The median calprotectin level among patients with active disease was 68 mg/l which was significantly different from the latter group (p < 0.0001). Furthermore, we suggest that the degree of inflammation rather than the extent of the disease determined the faecal calprotectin levels. In conclusion, assessment of faecal calprotectin seems to be a marker of disease activity in patients with ulcerative colitis.