Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa
Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa
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DOI：
10.1093/cid/cis530
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发表时间：
2012-09-15
影响因子：
11.8
通讯作者：
Leroy, Eric Maurice
中科院分区：
文献类型：
--
作者：
Caron, Melanie;Paupy, Christophe;Leroy, Eric Maurice
背景。基孔肯雅病毒 (CHIKV) 和登革热病毒血清型 2 (DENV-2) 最近与白纹伊蚊一起被引入中部非洲。随后，2006 年在喀麦隆和 2007 年在加蓬同时爆发了 CHIKV 和 DENV-2。方法。为了研究这两种病毒的传播，我们在 2007 年至 2010 年间对加蓬各地的急性发热综合征进行了主动监测。诊断方法包括定量实时逆转录聚合酶链反应，分子表征基于部分包膜基因序列。结果。 2007年至2010年间，对4287例急性发热患者进行了CHIKV和DENV-2感染调查，其中1567例CHIKV阳性，376例DENV-2阳性，37例合并感染。 2008年，我们诊断出153例CHIKV和11例DENV-2病例，2009年诊断出5例CHIKV和9例DENV-2病例。2010年，CHIKV和DENV-2引起了第二次大规模同时爆发。在本次疫情期间检查的 2826 名急性发热患者中，1112 名 CHIKV 阳性，288 名 DENV-2 阳性，28 名合并感染。在合并感染患者家附近采集蚊子，发现1份白纹伊蚊标本对CHIKV和DENV-2均呈阳性。结论。这些发现表明，CHIKV 和 DENV-2 在热带非洲国家的非免疫人群中迅速传播，这可能是由于白纹伊蚊的传播而促进的。这导致了大规模的同时爆发，人类和蚊子之间出现了大量的双重感染。
Background. Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007.Methods. To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences.Results. Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2.Conclusions. These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito.