Risk factors for a first febrile convulsion in children: A population study in southern Taiwan
Risk factors for a first febrile convulsion in children: A population study in southern Taiwan
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DOI：
10.1111/j.1528-1157.1999.tb00769.x
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发表时间：
1999-06-01
期刊：
影响因子：
5.6
通讯作者：
Tsai, JJ
中科院分区：
文献类型：
--
作者：
Huang, CC;Wang, ST;Tsai, JJ
目的：通过配对病例对照人群研究，确定3岁儿童首次热性惊厥的危险因素。方法：1989年10月至1991年9月在台南市出生的11，714名新生儿存活。在3岁时，有10，460名儿童接受了热性惊厥的电话调查，并通过家访访谈得到证实。结果：256例热性惊厥患儿中，有218例可供分析。与对照组相比，热性惊厥病例每年的发热事件（四次或以上）明显更多（33.0%比22.5%; p = 0.021），并且病例的发育迟缓百分比更高（3.7%比0.4%; p = 0.046），其兄弟姐妹的热性惊厥百分比也更高（12%比0.4%; p = 0.011）。其他社会人口统计学、环境和生物学变量在病例组和对照组之间没有差异。逐步Logistic回归分析显示，兄弟姐妹的热性惊厥和热性惊厥史之间存在高度显著的独立相关性，而热性惊厥和每年热性发作次数之间存在中度相关性。在我们的人群中，兄弟姐妹中热性惊厥的存在和每年发热发作的次数是单个病例热性惊厥的独立和重要的预测因素。基于样本
Purpose: To identify risk factors for a first febrile convulsion among 3-year-old children by a matched case-control population study.Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for febrile convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each febrile convulsion case by age, gender, and residence district.Results: Two hundred fifty six children had febrile convulsions, and 218 of them and their matched controls were available far analysis. The febrile convulsion cases had significantly more febrile episodes (four or more) per year (33.0 vs. 22.5%; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4%; p = 0.046) and a higher percentage of febrile convulsions in their siblings (12 vs. 0.4%; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between febrile convulsions and history of febrile convulsions in the siblings, and a moderate one between febrile convulsions and the number of febrile episodes per year.Conclusions: The presence of febrile convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of febrile convulsion for an individual case in our population-based sample.