The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis
The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis
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预后不良感染人群家族聚集性HBV基因型分布及其临床意义
DOI：
10.1007/s00705-008-0239-y
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发表时间：
2008-11-01
影响因子：
2.7
通讯作者：
Zhao, Yingren
中科院分区：
文献类型：
--
作者：
Liu, Jinfeng;Li, Yongqin;Zhao, Yingren
应用巢式PCR技术对HBV聚集性感染家族（CIF）中的HBV感染者进行基因分型，并与无家族感染史的HBV感染者进行比较。CIF组中C基因型感染率显著增高，而B基因型则不存在。此外，在年龄小于50岁的C基因型携带者中，CIF中HCC和LC的患病率与对照组相比显著增加。我们发现HBeAg阳性的HBV基因型C携带者比基因型B感染者更容易发展为终末期肝病。
Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.