UNUSUAL HLA-B ALLELES IN 2 TRIBES OF BRAZILIAN INDIANS
UNUSUAL HLA-B ALLELES IN 2 TRIBES OF BRAZILIAN INDIANS
复制标题
DOI：
10.1038/357326a0
复制
发表时间：
1992-05-28
期刊：
影响因子：
64.8
通讯作者：
PARHAM, P
中科院分区：
文献类型：
--
作者：
BELICH, MP;MADRIGAL, JA;PARHAM, P
卡因冈人和瓜拉尼人是巴西南部文化和语言上截然不同的部落1,2。与所有美洲印第安人群体一样 3,4 他们表现出有限的 HLA 多态性，这可能反映了 11,000-40,000 年前从亚洲通过陆路移民殖民美洲的小型创始人群体 5,6。我们发现 Kaingang 人和瓜拉尼人的 HLA-B 等位基因的核苷酸序列与白种人、东方人和其他人群中的特征不同 7。相比之下，HLA-A 和 C 等位基因是熟悉的。这些结果以及厄瓜多尔瓦奥拉尼人的随附论文 8 中报道的结果表明，自人类首次进入南美洲以来，HLA-B 发生了显着的进化。新的等位基因是通过预先存在的等位基因之间的重组而不是点突变形成的，从而在不同的南美印第安部落中引起了 HLA-B 的独特多样化。
THE Kaingang and Guarani are culturally and linguistically distinct tribes of southern Brazil 1,2. Like all Amerindian groups 3,4 they show limited HLA polymorphism, which probably reflects the small founder populations that colonized America by overland migration from Asia 11,000-40,000 years ago, 5,6. We find the nucleotide sequences of HLA-B alleles from the Kaingang and Guarani to be distinct from those characterized in caucasian, oriental and other populations 7. By comparison, the HLA-A and C alleles are familiar. These results and those reported in the accompanying paper 8 on the Waorani of Ecuador reveal that a marked evolution of HLA-B has occurred since humans first entered South America. New alleles have been formed through recombination between pre-existing alleles, not by point mutation, giving rise to distinctive diversification of HLA-B in different South American Indian tribes.