Serum interleukin-6, interleukin-17A and tumor necrosis factor-alpha in patients with recurrent aphthous stomatitis.
Serum interleukin-6, interleukin-17A and tumor necrosis factor-alpha in patients with recurrent aphthous stomatitis.
复制标题
复发性口疮性口炎患者血清白细胞介素 6、白细胞介素 17A 和肿瘤坏死因子 α。
DOI：
10.1111/jop.13158
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
H. Yao
中科院分区：
文献类型：
--
作者：
Chenlu Shen;Weijia Ye;Lijun Gong;Ke;B. Gao;H. Yao
背景
复发性口腔炎仍然是口腔黏膜最常见的疾病。本研究的目的是探讨复发性口腔炎患者血清白介素6、白介素17A和肿瘤坏死因子-α的临床意义。
方法
采用流式细胞仪检测127例复发性口腔炎患者和20例健康对照组血清IL-2、IL-6、IL-17A、肿瘤坏死因子-α、干扰素-γ水平，比较分析各指标之间的相关性。
结果
复发性口腔炎患者血清IL-2、IL-6、肿瘤坏死因子-α、干扰素-γ水平均高于对照组，差异有统计学意义(P<；0.05)。白介素17A在两组间差异无统计学意义。
结论
复发性口腔炎患者血清IL-6、肿瘤坏死因子-α水平显著升高。鉴于血清肿瘤坏死因子-α大多在正常范围内，其在RAS发病机制中的作用有待进一步探讨。
BACKGROUND
Recurrent aphthous stomatitis remains the most common disease of the oral mucosa. The aim of this study was to investigate the clinical significance of serum interleukin-6, interleukin-17A, and tumor necrosis factor-alpha in recurrent aphthous stomatitis.
METHODS
Using flow cytometry analysis, detect the level of serum interleukin-2, interleukin-6, interleukin-17A, tumor necrosis factor-alpha, and interferon-gamma in 127 patients with recurrent aphthous stomatitis and 20 healthy control cases, compare and analyze the correlation of each index.
RESULTS
The levels of serum interleukin-2, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma in the recurrent aphthous stomatitis group were higher than in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in interleukin-17A between the two groups.
CONCLUSION
The levels of serum interleukin-6, tumor necrosis factor-alpha in recurrent aphthous stomatitis patients were significantly increased. Considering that serum TNF-α was mostly within the normal range, its role in the pathology of RAS needed to be further explored.