Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation
Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation
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DOI：
10.1016/s0730-725x(01)00391-5
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发表时间：
2001-07-01
影响因子：
2.5
通讯作者：
Van der Linden, A
中科院分区：
文献类型：
--
作者：
Peeters, RR;Tindemans, I;Van der Linden, A
在fMRI实验中，就BOLD信号响应而言，研究了清醒curatized和α-chloralise麻醉动物之间的差异。通过研究电刺激同一大鼠前爪时皮层的激活。但在连续应用箭毒化和α-氯醛糖麻醉方案后，可以定量比较两种固定方案对fMRI数据的影响。在清醒状态下发现前爪刺激导致的最大BOLD信号变化，然而激活区域的特异性低于麻醉状态下的区域，使得其更难以解释。(C)2001 Elsevier Science Inc. All rights reserved.
The difference between awake curarized and alpha -chloralise anesthetized animals was studied with respect to the BOLD signal response in an fMRI experiment. By studying the activation of the cortex upon electrical forepaw stimulation in the same rat. but following consecutively applied curarization and alpha -chloralose anesthesia protocols, it was possible to compare quantitatively the effect of both immobilization protocols on the fMRI data. The largest BOLD signal change as a result of forepaw stimulation was found in the awake condition, however the activated areas are less specific than those in the anesthetized state leaving it more difficult to interpret. (C) 2001 Elsevier Science Inc. All rights reserved.