Epstein-Barr-virus induced lymphoproliferation. Implications for antiviral chemotherapy.
Epstein-Barr-virus induced lymphoproliferation. Implications for antiviral chemotherapy.
复制标题
Epstein-Barr病毒诱导淋巴细胞增殖。
DOI：
10.1056/nejm198411013111806
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Mulder,C
中科院分区：
文献类型：
--
作者：
Sullivan,JL;Medveczky,P;Forman,SJ;Baker,SM;Monroe,JE;Mulder,C
EPSTEIN-BARR 病毒 (EBV) 是一种转化性疱疹病毒，可感染 B 淋巴细胞并在其中复制，人们越来越认识到它是导致免疫缺陷宿主淋巴组织增殖性疾病的原因。患有 X 连锁淋巴增殖综合征的男性、1,2 接受肾移植、3 骨髓移植、4 或心脏移植的患者、5 以及患有严重联合免疫缺陷、6 共济失调性毛细血管扩张症、7 或获得性免疫缺陷综合征 8 的患者患有致命的 EB 病毒诱导的淋巴增殖性疾病。正常人很少会死于 EB 病毒诱导的淋巴增殖性疾病 9，包括中枢神经系统的疾病。 10 这些疾病的治疗尚未特别成功，抗病毒药物正在研究中。最近发现其中一种药物阿昔洛韦（9-[2-羟基乙氧基甲基]鸟嘌呤）具有抗病毒作用。 。 。
EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome,1,2recipients of renal,3bone-marrow,4or cardiac transplants,5and patients with severe combined immunodeficiency,6ataxia telangiectasia,7or the acquired immunodeficiency syndrome8have had fatal EBV-induced lymphoproliferative disorders. Infrequently, normal persons may die of EBV-induced lymphoproliferative disorders9including those of the central nervous system.10Treatment of these disorders has not been particularly successful, and antiviral agents are being investigated.One such agent, acyclovir (9-[2-hydroxyethoxy-methyl] guanine) was recently found to be . . .