Effect of drug type on the degradation rate of PLGA matrices
Effect of drug type on the degradation rate of PLGA matrices
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DOI：
10.1016/j.ejpb.2006.06.009
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发表时间：
2006-11-01
影响因子：
4.9
通讯作者：
Dan, Nily
中科院分区：
文献类型：
--
作者：
Siegel, Steven J.;Kahn, Jonathan B.;Dan, Nily
我们比较了六种不同药物（硫代噻吨、氟哌啶醇、氢氯噻嗪、皮质酮、依匹林和阿司匹林）通过50：50聚乳酸-羟基乙酸共聚物微丸降解的药物释放速率。尽管使用相同的聚合物基质和载药量（20%重量），我们发现，聚合物降解速率和药物释放曲线显着不同的药物之间。我们的结论是，高载药量的生物可降解聚合物药物载体的设计必须考虑药物对聚合物降解和药物释放速率的影响。(c)2006 Elsevier B. V.保留所有权利。
We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate. (c) 2006 Elsevier B.V. All rights reserved.