Antenatal Antecedents of Cognitive Impairment at 24 Months In Extremely Low Gestational Age Newborns
Antenatal Antecedents of Cognitive Impairment at 24 Months In Extremely Low Gestational Age Newborns
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DOI：
10.1542/peds.2011-1796
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发表时间：
2012-03-01
期刊：
影响因子：
8
通讯作者：
Leviton, Alan
中科院分区：
文献类型：
--
作者：
Helderman, Jennifer B.;O'Shea, Thomas M.;Leviton, Alan
背景和目的：极低胎龄儿比足月儿更容易发生认知障碍。很少有研究涉及这种情况的产前危险因素。我们确定了由贝利婴儿发育量表第二版(BSID-II)中的智力发展指数(MDI)部分确定的产前认知障碍的先兆因素，校正年龄为24个月。方法：我们研究了2002至2004年间出生于28周之前的921名婴儿的多中心队列，并评估了他们的胎盘组织学特征和微生物。这位母亲接受了面谈，并查阅了她的医疗记录。在调整年龄24个月时，采用BSID-II对儿童进行评估。结果：共有103名婴儿(11%)患有MDI。
BACKGROUND AND OBJECTIVES: Extremely low gestational age neonates are more likely than term infants to develop cognitive impairment. Few studies have addressed antenatal risk factors of this condition. We identified antenatal antecedents of cognitive impairment determined by the Mental Development Index (MDI) portion of the Bayley Scales of Infant Development, Second Edition (BSID-II), at 24 months corrected age.METHODS: We studied a multicenter cohort of 921 infants born before 28 weeks of gestation during 2002 to 2004 and assessed their placentas for histologic characteristics and microorganisms. The mother was interviewed and her medical record was reviewed. At 24 months adjusted age, children were assessed with BSID-II. Multinomial logistic models were used to estimate odds ratios.RESULTS: A total of 103 infants (11%) had an MDI