Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
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DOI：
10.1007/s11130-009-0112-5
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发表时间：
2009-06-01
影响因子：
4
通讯作者：
Kukongviriyapan, Upa
中科院分区：
文献类型：
--
作者：
Naowaboot, Jarinyaporn;Pannangpetch, Patchareewan;Kukongviriyapan, Upa
在泰国，含有桑叶的饮料(Morus Alba L.)被认为能促进健康，尤其是对糖尿病患者。我们研究了长期服用桑叶乙醇提取物(MA)对链脲佐菌素诱导的糖尿病大鼠血糖、氧化损伤和糖基化的影响。每天服用1g/kg的MA，连续6周，血糖下降22%，与4U/kg胰岛素的效果相当。脂质过氧化指标丙二醛和脂质过氧化氢浓度(分别为3.50+/-0.33和3.76+/-0.18 mU)显著低于未治疗对照组糖尿病大鼠(分别为8.19+/-0.45和7.50+/-0.46 mU)(P<；0.05)。长期接触高浓度葡萄糖的生物标志物--血红蛋白A(1C)在MA治疗组(6.78+/-0.30%)也显著低于未治疗组(9.02+/-0.30%)。体外抗糖和清除自由基活性的IC50分别为16.4+/-5.6mU/ml和61.7+/-2.1mU/ml。这些结果支持长期服用MA对慢性糖尿病大鼠具有降血糖、抗氧化和降血糖的作用，这可能是糖尿病患者有益的食物补充。
In Thailand, beverages containing mulberry leaf (Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of mulberry leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 +/- 0.33 and 3.76 +/- 0.18 mu M, respectively) decreased significantly (P < 0.05) compared to nontreated control diabetic rats (8.19 +/- 0.45 and 7.50 +/- 0.46 mu M, respectively). Hemoglobin A(1C), a biomarker for chronic exposure to high concentration of glucose, was also significantly decreased in the MA-treated group (6.78 +/- 0.30%) in comparison to untreated group (9.02 +/- 0.30%). The IC50 of in vitro antiglycation and free radical scavenging activities of MA were 16.4 +/- 5.6 mu g/ml and 61.7 +/- 2.1 mu g/ml, respectively. These findings support that long-term administration of MA has antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may be beneficial as food supplement for diabetics.