Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade
Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade
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通过铂催化的Sigmatropic重排/环化级联合成多取代吡唑
DOI：
10.1021/ol502968c
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发表时间：
2014-11-21
期刊：
影响因子：
5.2
通讯作者：
Zhan, Zhuang-Ping
中科院分区：
文献类型：
--
作者：
Wen, Jia-Jie;Tang, Hai-Tao;Zhan, Zhuang-Ping
报道了一种高效的Pt催化的N-炔丙基腙[3，3] σ迁移重排/环化级联反应。该方法提供了方便地获得各种高度官能化的吡唑。该底物具有良好的取代基相容性，可方便地合成具有生物活性的3-CF 3吡唑类化合物。
A highly efficient Pt-catalyzed [3,3] sigmatropic rearrangement/cyclization cascade of N-propargylhydrazones is reported. The process provides expedient access to a variety of highly functionalized pyrazoles. The substrate has good substituted group compatibility, and the bioactive 3-CF3 pyrazoles could be synthesized easily with this method.