Myelodysplastic syndromes (MDS) in Central Africans.
Myelodysplastic syndromes (MDS) in Central Africans.
复制标题
中非人的骨髓增生异常综合征（MDS）。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
B. Paul
中科院分区：
文献类型：
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作者：
JM Mukiibi;B. Paul
报道了津巴布韦大学哈拉雷血液学系的42名患者，他们在6年的时间里接受了法美英(FAB)骨髓增生异常综合征(MDS)的诊断标准。年龄范围29~75岁，平均+/-SD为57.8+/-11.2岁。难治性贫血(RA)占33.3%，环状铁粒母细胞(RARS)占16.7%，难治性贫血伴原始细胞增多(RAEB)占21.4%，转化中原始细胞增多的难治性贫血(RAEB-T)占16.7%，慢性粒单核细胞白血病(CMML)占11.9%。90.5%的人是原发疾病，9.5%的人以前接触过骨髓毒性药物会导致继发性MDS。这项研究表明，由于疟疾猖獗、营养不良和一系列营养不足，MDS作为非洲人口贫血的原因通常隐藏在大量众所周知的贫血中。因此，有必要提高我们的临床医生对这些疾病的存在的诊断意识。
Forty two patients who were seen and satisfied the French-American-British (FAB) diagnostic criteria for myelodysplastic syndromes (MDS) over a 6-year period at the University of Zimbabwe's Department of Haematology, Harare, are presented. Their overall ages ranged from 29 to 75 years with a mean +/- SD of 57.8 +/- 11.2 years. Males outnumbered females with a male to female ratio of 1.2:1. Refractory anaemia (RA) occurred in 33.3%; refractory anaemia with ringed sideroblasts (RARS) in 16.7%; refractory anaemia with excess blasts (RAEB) in 21.4%; refractory anaemia with excess blasts in transformation (RAEB-T) in 16.7% and chronic myelomonocytic leukaemia (CMML) in 11.9% of the patients. In 90.5% the disease was primary and in 9.5% prior exposure to myelotoxic agents resulted in secondary MDS. The study reveals that MDS as a cause of anaemia in the African population is usually hidden in the big number of well known anaemias due to rampant malaria, malnutrition and a host of nutritional deficiencies. There is therefore the need to increase diagnostic awareness among our clinicians about the existence of these disorders.