[P2-347]: SQSTM1 MUTATIONS IN FRONTOTEMPORAL DEMENTIA ARE ASSOCIATED WITH ASYMMETRICAL FOCAL TEMPORAL LOBE ATROPHY
[P2-347]: SQSTM1 MUTATIONS IN FRONTOTEMPORAL DEMENTIA ARE ASSOCIATED WITH ASYMMETRICAL FOCAL TEMPORAL LOBE ATROPHY
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[P2-347]：额颞叶痴呆中的 SQSTM1 突变与不对称局灶性颞叶萎缩有关
DOI：
10.1016/j.jalz.2017.06.1001
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Boretska S
中科院分区：
文献类型：
--
作者：
Boretska S
背景 FTD 是年轻发病痴呆症的常见原因，大约三分之一的病例是遗传性的。最近，SQSTM1 突变已被证明是家族性 FTD 的罕见原因。目前对临床或神经解剖表型知之甚少。在这项研究中，我们调查了一组 SQSTM1 相关 FTD 患者的灰质萎缩模式。
BackgroundFTD is a common cause of young onset dementia and in around a third of cases is genetic. Recently mutations in SQSTM1 have been shown to be a rare cause of familial FTD. Little is known about the clinical or neuroanatomical phenotype at present. In this study, we investigated the pattern of grey matter atrophy in a group of patients with SQSTM1-associated FTD.