Weak distance dependence of excess electron transfer in DNA
Weak distance dependence of excess electron transfer in DNA
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DOI：
10.1002/1521-3773(20020517)41:10
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发表时间：
2002-01-01
影响因子：
16.6
通讯作者：
Carell, T
中科院分区：
文献类型：
--
作者：
Behrens, C;Burgdorf, LT;Carell, T
DNA中的电子转移现象对DNA损伤和DNA修复具有重要意义在这种情况下，正电荷（空穴）通过DNA的运动在过去几年中得到了深入的研究。[3±6]在关于双链DNA的空穴导电性的争论之后[7,8]，现在人们接受了正电荷可以在DNA中移动很远的距离两种机制，即小转移距离的相干超交换[10,11]和远距离转移的空穴[4]或极化子跳变[6]来描述这一现象。实验表明，远程空穴转移需要中间的鸟嘌呤，在较小程度上也需要腺嘌呤作为暂时可氧化的垫脚石远程空穴转移是否具有生物学后果尚不清楚，但有推测认为，这一过程可能定义了氧化应激过程中受损的基因组位点
Electron transfer phenomena in DNA are of fundamental importance for DNA damage [1] and DNA repair.[2] In this context, the movement of a positive charge (hole) through DNA has been studied intensively over the past few years.[3±6] After a controversial debate about the™ hole conductivity∫ of double-stranded DNA,[7, 8] it is now accepted that a positive charge can move through DNA over significant distances.[9] Two mechanisms, namely coherent superexchange for small transfer distances [10, 11] and hole [4] or polaron hopping [6] for long-range transfer are evoked to describe this phenomenon. Experimentally, it is becoming clear that long-range hole transfer requires intermediate guanines and to a lesser extent also adenines to function as temporarily oxidizable™ stepping stones∫.[12] Whether long-range hole transfer has biological consequences is unclear, but there are speculations that the process might define the genome sites damaged during oxidative stress.[13]