Absence of the c-Ha-ras codon 61 point mutation in murine solid tumors induced by subcutaneously applied 7,12-dimethylbenzanthracene.
Absence of the c-Ha-ras codon 61 point mutation in murine solid tumors induced by subcutaneously applied 7,12-dimethylbenzanthracene.
复制标题
皮下应用 7,12-二甲基苯并蒽诱导的小鼠实体瘤中不存在 c-Ha-ras 密码子 61 点突变。
DOI：
10.1016/0304-3835(90)90035-v
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发表时间：
1990
期刊：
影响因子：
9.7
通讯作者：
Reddy,AL
中科院分区：
文献类型：
--
作者：
Andrews3rd,DF;Collins,SJ;Reddy,AL
The c-Ha-ras-1 codon 61 A→T transversion is a highly consistent finding in murine skin DMBA-initiated/TPA-promoted papillomas and carcinomas. We performed Xba I RFLP analysis on DNA from clonal cell lines derived from 11 independent papillomas and a single carcinoma derived from topically applied DMBA and compared this to RFLP on DNA from 7 clonal fibrosarcoma cell lines derived from tumors arising after subcutaneous administration of the same carcinogen. The A→T point mutation was present in all of the papillomas and carcinoma derived by the classic DMBA-TPA protocol but was absent in all of the fibrosarcomas arising after subcutaneous administration of DMBA.
